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Article

Rapamycin decelerates cellular senescence

15 Jun 2009

Abstract excerpt

When the cell cycle is arrested but cellular growth is not, then cells senesce, permanently losing proliferative potential. Here we demonstrated that the duration of cell cycle arrest determines a progressive loss of proliferative capacity. In human and rodent cell lines, rapamycin (an inhibitor of mTOR) dramatically decelerated loss of proliferative potential caused by ectopic p21, p16 and sodium...

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PMID: 19471117
DOI: 10.4161/cc.8.12.8606

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