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Article

Prospective clinical and DaT-SPECT imaging in premotor LRRK2 G2019S-associated Parkinson disease.

Neurology - 1 Aug 2017

Sierra María, Martínez-Rodríguez Isabel, Sánchez-Juan Pascual, González-Aramburu Isabel, Jiménez-Alonso Mikel, Sánchez-Rodríguez Antonio, Berciano José, Banzo Ignacio, Infante Jon

Abstract excerpt

OBJECTIVE: To assess the value of baseline clinical and imaging biomarkers in a cohort of asymptomatic LRRK2 G2019S carriers for predicting conversion to Parkinson disease (PD) at 4 years. METHODS: Thirty-two asymptomatic carriers of LRRK2 G2019S mutation underwent baseline and 4-year evaluation including clinical examination (Unified Parkinson's Disease Rating Scale, part III, olfaction University of...

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PMID: 28679601
DOI: 10.1212/WNL.0000000000004185
PMCID: PMC5539730

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