Article
Clinical Features of LRRK2 Carriers with Parkinson's Disease.
Advances in neurobiology - 1 Jan 2017
Kestenbaum Meir, Alcalay Roy N
Abstract excerpt
LRRK2 mutations are present in 1% of all sporadic Parkinson's disease (PD) cases and 5% of all familial PD cases. Several mutations in the LRRK2 gene are associated with PD, the most common of which is the Gly2019Ser mutation. In the following review, we summarize the demographics and motor and non-motor symptoms of LRRK2 carriers with PD, as well as symptoms in non-manifesting carriers. The clinical features of...
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