Article
Polyphenic trait promotes liver cancer in a model of epigenetic instability in mice.
Hepatology (Baltimore, Md.) - 1 Jul 2017
Cassano Marco, Offner Sandra, Planet Evarist, Piersigilli Alessandra, Jang Suk Min, Henry Hugues, Geuking Markus B, Mooser Catherine, McCoy Kathy D, Macpherson Andrew J, Trono Didier
Abstract excerpt
Hepatocellular carcinoma (HCC) represents the fifth-most common form of cancer worldwide and carries a high mortality rate attributed to lack of effective treatment. Males are 8 times more likely to develop HCC than females, an effect largely driven by sex hormones, albeit through still poorly understood mechanisms. We previously identified TRIM28 (tripartite protein 28), a scaffold protein capable of recruiting...
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