Article

Female-specific m6A remodeling in the liver correlates with post-transcriptional metabolic adaptation to high fat diet

2026-06-22

Abstract excerpt

<h4>Summary</h4> Sex differences strongly influence susceptibility to metabolic dysfunction-associated steatotic liver disease (MASLD), yet the regulatory mechanisms underlying these differences remain incompletely understood. To examine sex-specific hepatic adaptation to a high-fat (HF) diet mouse model of MASLD, we integrated proteomics, transcriptomics, and Oxford Nanopore direct RNA sequencing for transcripto...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 11e6088a-c483-52c1-babf-7d1937424f6a
DOI: 10.64898/2026.06.19.733425

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Female-specific m6A remodeling in the liver correlates with post-transcriptional metabolic adaptation to high fat dietDOI 10.64898/2026.06.19.733425Read

Sex-specific lipid-mediated mechanisms drive MASLD progression revealed by paired liver–blood multi-omicsSemantic proximity Read

Sex- and age-associated factors drive the pathophysiology of MASLDSemantic proximity Read

Single transcript-level metabolic responsive landscape of human liver transcriptomeSemantic proximity Read

Loss of Carnitine Palmitoyltransferase 1a Reduces Docosahexaenoic Acid-Containing Phospholipids and Drives Sexually Dimorphic Liver Disease in MiceSemantic proximity Read

Proteome-wide QTL mapping enables gene-protein-phenotype metabolic network construction in a genetically diverse MASLD mouse modelSemantic proximity Read

Integrative study of diet-induced mouse models of NAFLD identifies PPARα as a sexually dimorphic drug targetSemantic proximity Read

Sex-Specific Gene Expression in MASLD: A Transcriptomic and Systems Biology Analysis Reveals Key Regulatory Modules and Immune NetworksSemantic proximity Read

Genetic background and sex control the outcome of high-fat diet feeding in miceSemantic proximity Read

Role of STAT5a in regulation of sex-specific gene expression in female but not male mouse liver revealed by microarray analysisSemantic proximity Read

Sex-specific KDM6A-HNF4A-CREBH network controls lipoprotein cholesterol metabolism and atherosclerosis via epigenetic reprograming of hepatocytesSemantic proximity Read

Transcriptomic responses are sex-dependent in the skeletal muscle and liver in offspring of obese miceSemantic proximity Read

Alterations in the hepatocyte epigenetic landscape in steatosisSemantic proximity Read