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Erythroid Krüppel-Like Factor (KLF1): A Surprisingly Versatile Regulator of Erythroid Differentiation.

Advances in experimental medicine and biology - 1 Jan 2024

Bieker James J, Philipsen Sjaak

Abstract excerpt

Erythroid Krüppel-like factor (KLF1), first discovered in 1992, is an erythroid-restricted transcription factor (TF) that is essential for terminal differentiation of erythroid progenitors. At face value, KLF1 is a rather inconspicuous member of the 26-strong SP/KLF TF family. However, 30 years of research have revealed that KLF1 is a jack of all trades in the molecular control of erythropoiesis. Initially...

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PMID: 39017846
DOI: 10.1007/978-3-031-62731-6_10

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