Article
Association of Toll-like receptor 3 rs3775291 with Zika virus infection in Brazil.
Transactions of the Royal Society of Tropical Medicine and Hygiene - 3 Nov 2025
Ayo Christiane Maria, de Moraes Amarilis Giaretta, Elpídio Laise Nayana Sala, Yamanaka Aléia Harumi Uchibaba, de Souza Victor Hugo, Lo Ré Fernanda Morselli, Pinho Tainara, Nogueira Maurício Lacerda, Brandão Cinara de Cássia, Spegiorin Lígia Consentino Junqueira Franco, Oliani Denise Cristina Moz Vaz, Zini Nathalia, Langer Ieda Bernadete Volkweis, Amaral Greicy Cezar do, de Lima Neto Quirino Alves, de Mattos Luiz Carlos, Visentainer Jeane Eliete Laguila
Abstract excerpt
BACKGROUND: Zika virus (ZIKV) is an emergent pathogen known for the outbreak in early 2015, causing significant consequences, of which congenital ZIKV syndrome is the most severe manifestation. Toll-like receptors (TLRs) are important for the appropriate function of the innate immune response against pathogens. The presence of mutations in TLR genes can potentially result in altered susceptibility to diseases....
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