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Article

Rare Genetic Variants in Immune Genes and Neonatal Herpes Simplex Viral Infections.

Pediatrics - 1 Jan 2021

Cummings Lauren, Tucker Megan, Gibson Margaret, Myers Angela, Pastinen Tomi, Johnston Jeffrey, Farrow Emily, Sampath Venkatesh

Abstract excerpt

Neonatal herpes simplex virus (HSV) infection is a devastating disease with high mortality, particularly when disseminated. Studies in adults and children suggest that susceptibility to herpes simplex encephalitis (HSE) may represent phenotypes for inborn errors in toll-like receptor 3 (TLR3) signaling. However, the genetic basis of susceptibility to neonatal HSV including disseminated disease remains unknown. To...

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Complement C7
GRB2 Adaptor Protein
Herpes Simplex
Interferon Regulatory Factor-3
Perforin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA Nucleotidyltransferases

Scavenger Receptors, Class A

Toll-Like Receptor 3

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PMID: 33386334
DOI: 10.1542/peds.2020-0687

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