Are the estrogen receptor and SIRT3 axes of the mitochondrial UPR key regulators of breast cancer subtype determination according to age?

Abstract excerpt

Abstract Aging is a major risk factor of developing breast cancer. Despite the fact that postmenopausal women have lower levels of estrogen, older women have a higher rate of estrogen receptor alpha (ERα)‐positive breast cancer. Conversely, young women who have elevated levels of estrogen tend to develop ERα‐negative disease that is associated with higher rate of metastasis. This perspective proposes a unifying...

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