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Article

Tracking the fate and origin of clinically relevant adoptively transferred CD8 + T cells in vivo

24 Feb 2017

Abstract excerpt

post-transfer frequencies of the top 25 HTTCS-defined clonotypes originally detected in the infused CTL population were comparable to enumeration by binding of antigen peptide-HLA multimers, revealing quantitative HTTCS is a reliable, multimer-independent alternative. Surprisingly, the polyclonal CTL products were composed predominantly of clonotypes that were of very low frequency (VLF) in the endogenous...

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PMID: 28367538
DOI: 10.1126/sciimmunol.aal2568

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