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Article

Clinical and basic implications of dynamic T cell receptor clonotyping in hematopoietic cell transplantation

7 Jul 2021

Abstract excerpt

TCR repertoire diversification constitutes a foundation for successful immune reconstitution after allogeneic hematopoietic cell transplantation (allo-HCT). Deep TCR Vβ sequencing of 135 serial specimens from a cohort of 35 allo-HCT recipients/donors was performed to dissect posttransplant TCR architecture and dynamics. Paired analysis of clonotypic repertoires showed a minimal overlap with donor expansions....

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PMID: 34236054
DOI: 10.1172/jci.insight.149080

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