Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Infusion of donor-derived CD8+ memory T cells for relapse following allogeneic hematopoietic cell transplantation.

Blood advances - 27 Mar 2018

Muffly Lori, Sheehan Kevin, Armstrong Randall, Jensen Kent, Tate Keri, Rezvani Andrew R, Miklos David, Arai Sally, Shizuru Judith, Johnston Laura, Meyer Everett, Weng Wen-Kai, Laport Ginna G, Negrin Robert S, Strober Sam, Lowsky Robert

Abstract excerpt

Murine models showed that CD8+CD44hi memory T (TM) cells could eradicate malignant cells without inducing graft-versus-host disease (GVHD). We evaluated the feasibility and safety of infusing freshly isolated and purified donor-derived phenotypic CD8+ TM cells into adults with disease relapse after allogeneic hematopoietic cell transplantation (HCT). Phenotypic CD8 TM cells were isolated after unmobilized donor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD8-Positive T-Lymphocytes
Share to Graft vs Host Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunologic Memory

Share to Kaplan-Meier Estimate

Share to Recurrence

Share to T-Lymphocyte Subsets

Share to Tissue Donors

Share to Transplantation, Homologous

Source

Open in PubMed Open full text

Identifiers

PMID: 29572391
DOI: 10.1182/bloodadvances.2017012104
PMCID: PMC5873230

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Infusion of donor-derived CD8+ memory T cells for relapse following allogeneic hematopoietic cell transplantation.PMID 29572391Read ↗

Expansion, persistence and efficacy of donor memory-like NK cells for the treatment of post-transplant relapseSemantic proximity Read ↗

TLI and ATG conditioning with low risk of graft-versus-host disease retains antitumor reactions after allogeneic hematopoietic cell transplantation from related and unrelated donorsSemantic proximity Read ↗

Proceedings from the National Cancer Institute's Second International Workshop on the Biology, Prevention, and Treatment of Relapse after Hematopoietic Stem Cell Transplantation: Part I. Biology of Relapse after TransplantationSemantic proximity Read ↗

CD8+CD44(hi) but not CD4+CD44(hi) memory T cells mediate potent graft antilymphoma activity without GVHD.Semantic proximity Read ↗

Phenotypic and functional attributes of lentivirus-modified CD19-specific human CD8+ central memory T cells manufactured at clinical scale.Semantic proximity Read ↗

Overcoming the challenges of primary resistance and relapse after CAR-T cell therapySemantic proximity Read ↗

PD-1/PD-L1 Interactions Contribute to Functional T-Cell Impairment in Patients Who Relapse with Cancer After Allogeneic Stem Cell TransplantationSemantic proximity Read ↗

Relapse after Allogeneic Hematopoietic Cell TherapySemantic proximity Read ↗

Donor lymphocyte infusion for prevention of relapse after unmanipulated haploidentical PBSCT for very high-risk hematologic malignancies.Semantic proximity Read ↗

Prophylactic donor-derived CD19 CAR-T cell infusion for preventing relapse in high-risk B-ALL after allogeneic hematopoietic stem cell transplantationSemantic proximity Read ↗

Tumor-Specific CD8 <sup>+</sup> T Cells from the Bone Marrow Resist Exhaustion and Exhibit Increased Persistence in Tumor-Bearing Hosts as Compared to Tumor Infiltrating LymphocytesSemantic proximity Read ↗

Inflammatory CD4/CD8 double-positive human T cells arise from reactive CD8 T cells and are sufficient to mediate GVHD pathologySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.