Tracking genetically engineered lymphocytes long-term reveals the dynamics of T cell immunological memory.

doi:10.1126/scitranslmed.aac8265

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Article

Tracking genetically engineered lymphocytes long-term reveals the dynamics of T cell immunological memory.

Science translational medicine - 9 Dec 2015

Oliveira Giacomo, Ruggiero Eliana, Stanghellini Maria Teresa Lupo, Cieri Nicoletta, D'Agostino Mattia, D'Agostino Mattio, Fronza Raffaele, Lulay Christina, Dionisio Francesca, Mastaglio Sara, Greco Raffaella, Peccatori Jacopo, Aiuti Alessandro, Ambrosi Alessandro, Biasco Luca, Bondanza Attilio, Lambiase Antonio, Traversari Catia, Vago Luca, von Kalle Christof, Schmidt Manfred, Bordignon Claudio, Ciceri Fabio, Bonini Chiara

Abstract excerpt

Long-lasting immune protection from pathogens and cancer requires the generation of memory T cells able to survive long-term. To unravel the immunological requirements for long-term persistence of human memory T cells, we characterized and traced, over several years, T lymphocytes genetically modified to express the thymidine kinase (TK) suicide gene that were infused in 10 patients after haploidentical...

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PMID: 26659572
DOI: 10.1126/scitranslmed.aac8265

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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