Article
Tissue-restricted T cell alloresponses across HLA barriers: selection and identification of leukemia-restricted CTL in HLA-mismatched stimulator-responder pairs.
Bone marrow transplantation - 1 Aug 2003
Fujiwara H, Sconocchia G, Melenhorst J, Eniafe R, Nakamura R, Hensel N, Barrett A J
Abstract excerpt
Exploiting the graft-versus-leukemia (GVL) effect in mismatched transplants requires its separation from graft-versus-host disease (GVHD). We generated leukemia-specific cytotoxic T lymphocytes (CTL) in three haplotype-mismatched, two class I-mismatched and two single HLA-A locus-matched stimulator-responder pairs. Six patients with chronic myelogenous leukemia and one patient with acute myeloid leukemia...
Topics
- Bone Marrow Transplantation
- CD4-Positive T-Lymphocytes
- CD57 Antigens
- CD8-Positive T-Lymphocytes
- Cell Division
- Cell Line, Tumor
- Flow Cytometry
- Graft vs Host Disease
- Graft vs Leukemia Effect
- HLA Antigens
- Haplotypes
- Humans
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive