Article
Interindividual variability in hepatic organic anion-transporting polypeptides and P-glycoprotein (ABCB1) protein expression: quantification by liquid chromatography tandem mass spectroscopy and influence of genotype, age, and sex.
Drug metabolism and disposition: the biological fate of chemicals - 1 Jan 2014
Prasad Bhagwat, Evers Raymond, Gupta Anshul, Hop Cornelis E C A, Salphati Laurent, Shukla Suneet, Ambudkar Suresh V, Unadkat Jashvant D
Abstract excerpt
Interindividual variability in protein expression of organic anion-transporting polypeptides (OATPs) OATP1B1, OATP1B3, OATP2B1, and multidrug resistance-linked P-glycoprotein (P-gp) or ABCB1 was quantified in frozen human livers (n = 64) and cryopreserved human hepatocytes (n = 12) by a validated liquid chromatography tandem mass spectroscopy (LC-MS/MS) method. Membrane isolation, sample workup, and LC-MS/MS...
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