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Article

Numb regulates somatic cell lineage commitment during early gonadogenesis in mice.

Development (Cambridge, England) - 1 May 2017

Lin Yi-Tzu, Barske Lindsey, DeFalco Tony, Capel Blanche

Abstract excerpt

During early gonadogenesis, proliferating cells in the coelomic epithelium (CE) give rise to most of the somatic cells in both XX and XY gonads. Previous dye-labeling experiments showed that a single CE cell could give rise to additional CE cells and to both supporting and interstitial cell lineages, implying that cells in the CE domain are multipotent progenitors, and suggesting that an asymmetric division is...

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Source

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Identifiers

PMID: 28360133
DOI: 10.1242/dev.149203
PMCID: PMC5450849

Genes

NUMB
LHX9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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