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Article

Loss of LKB1 leads to impaired epithelial integrity and cell extrusion in the early mouse embryo.

Journal of cell science - 1 Mar 2015

Krawchuk Dayana, Anani Shihadeh, Honma-Yamanaka Nobuko, Polito Samantha, Shafik Marian, Yamanaka Yojiro

Abstract excerpt

LKB1/PAR-4 is essential for the earliest polarization steps in Caenorhabditis elegans embryos and Drosophila oocytes. Although LKB1 (also known as STK11) is sufficient to initiate polarity in a single mammalian intestinal epithelial cell, its necessity in the formation and maintenance of mammalian epithelia remains unclear. To address this, we completely remove LKB1 from mouse embryos by generating...

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Identifiers

PMID: 25588837
DOI: 10.1242/jcs.162156

Genes

STK11

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Loss of LKB1 leads to impaired epithelial integrity and cell extrusion in the early mouse embryo.PMID 25588837Read ↗

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