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Article

Ribosomal transcription is regulated by PGC-1alpha and disturbed in Huntington’s disease

11 Aug 2017

Abstract excerpt

PGC-1α is a versatile inducer of mitochondrial biogenesis and responsive to the changing energy demands of the cell. As mitochondrial ATP production requires proteins that derive from translation products of cytosolic ribosomes, we asked whether PGC-1α directly takes part in ribosomal biogenesis. Here, we show that a fraction of cellular PGC-1α localizes to the nucleolus, the site of ribosomal transcription by...

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PMID: 28819135
DOI: 10.1038/s41598-017-09148-7

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