Article
Selective Loss of Smaller Spines in Schizophrenia.
The American journal of psychiatry - 1 Jun 2017
MacDonald Matthew L, Alhassan Jamil, Newman Jason T, Richard Michelle, Gu Hong, Kelly Ryan M, Sampson Alan R, Fish Kenneth N, Penzes Peter, Wills Zachary P, Lewis David A, Sweet Robert A
Abstract excerpt
OBJECTIVE: Decreased density of dendritic spines in adult schizophrenia subjects has been hypothesized to result from increased pruning of excess synapses in adolescence. In vivo imaging studies have confirmed that synaptic pruning is largely driven by the loss of large or mature synapses. Thus, increased pruning throughout adolescence would likely result in a deficit of large spines in adulthood. Here, the...
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