Article

A Kalirin Missense Mutation Enhances Dendritic RhoA Signaling and Leads to Regression of Cortical Dendritic Arbors Across Development

2021-03-23

Abstract excerpt

<h4>ABSTRACT</h4> Normally, dendritic size is established prior to adolescence then remains relatively constant into adulthood due to a homeostatic balance between growth and retraction pathways. However, schizophrenia is characterized by accelerated reductions of cerebral cortex gray matter volume and onset of clinical symptoms during adolescence, with reductions in layer 3 pyramidal neuron dendritic length, com...

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Literature Corpus work: 6448638b-19e1-5a9d-b93f-1684044b4121
DOI: 10.1101/2021.03.22.436528

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