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Article

FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons.

Nature communications - 30 Mar 2017

Errichelli Lorenzo, Dini Modigliani Stefano, Laneve Pietro, Colantoni Alessio, Legnini Ivano, Capauto Davide, Rosa Alessandro, De Santis Riccardo, Scarfò Rebecca, Peruzzi Giovanna, Lu Lei, Caffarelli Elisa, Shneider Neil A, Morlando Mariangela, Bozzoni Irene

Abstract excerpt

The RNA-binding protein FUS participates in several RNA biosynthetic processes and has been linked to the pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. Here we report that FUS controls back-splicing reactions leading to circular RNA (circRNA) production. We identified circRNAs expressed in in vitro-derived mouse motor neurons (MNs) and determined that the production of a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28358055
DOI: 10.1038/ncomms14741
PMCID: PMC5379105

Genes

FUS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons.PMID 28358055Read ↗

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Amyotrophic Lateral Sclerosis associated FUS mutation shortens mitochondria and induces neurotoxicitySemantic proximity Read ↗

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