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Article

ALS-linked FUS mutants affect the localization of U7 snRNP and replication-dependent histone gene expression in human cells.

Scientific reports - 4 Jun 2021

Gadgil Ankur, Walczak Agnieszka, Stępień Agata, Mechtersheimer Jonas, Nishimura Agnes Lumi, Shaw Christopher E, Ruepp Marc-David, Raczyńska Katarzyna Dorota

Abstract excerpt

Genes encoding replication-dependent histones lack introns, and the mRNAs produced are a unique class of RNA polymerase II transcripts in eukaryotic cells that do not end in a polyadenylated tail. Mature mRNAs are thus formed by a single endonucleolytic cleavage that releases the pre-mRNA from the DNA and is the only processing event necessary. U7 snRNP is one of the key factors that determines the cleavage site...

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Identifiers

PMID: 34088960
DOI: 10.1038/s41598-021-91453-3
PMCID: PMC8178370

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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ALS-linked FUS mutants affect the localization of U7 snRNP and replication-dependent histone gene expression in human cells.PMID 34088960Read ↗

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