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Article

ALS-associated FUS mutations result in compromised FUS alternative splicing and autoregulation.

PLoS genetics - 1 Oct 2013

Zhou Yueqin, Liu Songyan, Liu Guodong, Oztürk Arzu, Hicks Geoffrey G

Abstract excerpt

The gene encoding a DNA/RNA binding protein FUS/TLS is frequently mutated in amyotrophic lateral sclerosis (ALS). Mutations commonly affect its carboxy-terminal nuclear localization signal, resulting in varying deficiencies of FUS nuclear localization and abnormal cytoplasmic accumulation. Increasing evidence suggests deficiencies in FUS nuclear function may contribute to neuron degeneration. Here we report a...

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Identifiers

PMID: 24204307
DOI: 10.1371/journal.pgen.1003895
PMCID: PMC3814325

Genes

FUS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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