Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of the lncRNA transcriptome in mESC-derived motor neurons: Implications for FUS-ALS

1 Feb 2018

Abstract excerpt

Long non-coding RNAs (lncRNAs) are currently recognized as crucial players in nervous system development, function and pathology. In Amyotrophic Lateral Sclerosis (ALS), identification of causative mutations in FUS and TDP-43 or hexanucleotide repeat expansion in C9ORF72 point to the essential role of aberrant RNA metabolism in neurodegeneration. In this study, by taking advantage of an in vitro differentiation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis Research
Share to Cancer-related molecular mechanisms research
Share to Neurogenetic and Muscular Disorders Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29449089
DOI: 10.1016/j.scr.2018.01.037

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of the lncRNA transcriptome in mESC-derived motor neurons: Implications for FUS-ALSPMID 29449089Read ↗

lncRNA Sequencing Reveals Neurodegeneration-Associated FUS Mutations Alter Transcriptional Landscape of iPS Cells That Persists in Motor Neurons.Semantic proximity Read ↗

Long non-coding and coding RNAs characterization in Peripheral Blood Mononuclear Cells and Spinal Cord from Amyotrophic Lateral Sclerosis patientsSemantic proximity Read ↗

Single-cell RNA-sequencing reveals early mitochondrial dysfunction unique to motor neurons shared across FUS- and TARDBP-ALSSemantic proximity Read ↗

FUS Mutant Human Motoneurons Display Altered Transcriptome and microRNA Pathways with Implications for ALS Pathogenesis.Semantic proximity Read ↗

Integrated profiling of iPSC-derived motor neurons carrying C9orf72, FUS, TARDBP, or SOD1 mutations.Semantic proximity Read ↗

Downstream Effects of Mutations in SOD1 and TARDBP Converge on Gene Expression Impairment in Patient-Derived Motor Neurons.Semantic proximity Read ↗

Proteomics analysis of FUS mutant human motoneurons reveals altered regulation of cytoskeleton and other ALS-linked proteins via 3'UTR binding.Semantic proximity Read ↗

Long non coding RNAs and ALS: Still much to doSemantic proximity Read ↗

FUS Alters circRNA Metabolism in Human Motor Neurons Carrying the ALS-Linked P525L Mutation.Semantic proximity Read ↗

Single-cell RNA sequencing across isogenic <i>FUS</i> and <i>TARDBP</i> ALS lines reveals a shared early mitochondrial dysfunction unique to motor neuronsSemantic proximity Read ↗

FUS-regulated region- and cell-type-specific transcriptome is associated with cell selectivity in ALS/FTLDSemantic proximity Read ↗

The intriguing case of motor neuron disease: ALS and SMA come closerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.