Article

Wild-type FUS corrects ALS-like disease induced by cytoplasmic mutant FUS through autoregulation

2020-12-16

Abstract excerpt

Mutations in FUS, an RNA-binding protein involved in multiple steps of RNA metabolism, are associated with the most severe forms of amyotrophic lateral sclerosis (ALS). Accumulation of cytoplasmic FUS is likely to be a major culprit in the toxicity of FUS mutations. Thus, preventing cytoplasmic mislocalization of the FUS protein may represent a valuable therapeutic strategy. FUS binds to its own pre-mRNA creating...

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Literature Corpus work: 33a6dec7-833a-55ce-a68f-7e8a45b725d1
DOI: 10.1101/2020.12.16.423060

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