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Article

Mislocalised FUS mutants stall spliceosomal snRNPs in the cytoplasm.

Neurobiology of disease - 1 Jul 2013

Gerbino Valeria, Carrì Maria Teresa, Cozzolino Mauro, Achsel Tilmann

Abstract excerpt

Genes encoding RNA-binding proteins have frequently been implicated in various motor neuron diseases, but the particular step in RNA metabolism that is vulnerable in motor neurons remains unknown. FUS, a nuclear protein, forms cytoplasmic aggregates in cells affected by amyotrophic lateral sclerosis (ALS), and mutations disturbing the nuclear import of FUS cause the disease. It is extremely likely that the...

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Share to Cell Line, Transformed
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Motor Neurons

Share to Ribonucleoproteins, Small Nuclear

Share to RNA-Binding Protein FUS

Share to Spliceosomes

Share to Survival of Motor Neuron 1 Protein

Source

Identifiers

PMID: 23523636
DOI: 10.1016/j.nbd.2013.03.003

Genes

FUS
SMN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Mislocalised FUS mutants stall spliceosomal snRNPs in the cytoplasm.PMID 23523636Read ↗

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