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Article

FUS Alters circRNA Metabolism in Human Motor Neurons Carrying the ALS-Linked P525L Mutation.

International journal of molecular sciences - 6 Feb 2023

Colantoni Alessio, Capauto Davide, Alfano Vincenzo, D'Ambra Eleonora, D'Uva Sara, Tartaglia Gian Gaetano, Morlando Mariangela

Abstract excerpt

Deregulation of RNA metabolism has emerged as one of the key events leading to the degeneration of motor neurons (MNs) in Amyotrophic Lateral Sclerosis (ALS) disease. Indeed, mutations on RNA-binding proteins (RBPs) or on proteins involved in aspects of RNA metabolism account for the majority of familiar forms of ALS. In particular, the impact of the ALS-linked mutations of the RBP FUS on many aspects of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36834591
DOI: 10.3390/ijms24043181
PMCID: PMC9968238

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FUS Alters circRNA Metabolism in Human Motor Neurons Carrying the ALS-Linked P525L Mutation.PMID 36834591Read ↗

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