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Article

Characterization of FUS mutations in amyotrophic lateral sclerosis using RNA-Seq.

PloS one - 1 Jan 2013

van Blitterswijk Marka, Wang Eric T, Friedman Brad A, Keagle Pamela J, Lowe Patrick, Leclerc Ashley Lyn, van den Berg Leonard H, Housman David E, Veldink Jan H, Landers John E

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease resulting in severe muscle weakness and eventual death by respiratory failure. Although little is known about its pathogenesis, mutations in fused in sarcoma/translated in liposarcoma (FUS) are causative for familial ALS. FUS is a multifunctional protein that is involved in many aspects of RNA processing. To elucidate the role of FUS in ALS, we...

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Identifiers

PMID: 23577159
DOI: 10.1371/journal.pone.0060788
PMCID: PMC3620060

Genes

FUS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Characterization of FUS mutations in amyotrophic lateral sclerosis using RNA-Seq.PMID 23577159Read ↗

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