Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epithelial tension in the second heart field promotes mouse heart tube elongation.

Nature communications - 30 Mar 2017

Francou Alexandre, De Bono Christopher, Kelly Robert G

Abstract excerpt

Extension of the vertebrate heart tube is driven by progressive addition of second heart field (SHF) progenitor cells to the poles of the heart. Defects in this process cause a spectrum of congenital anomalies. SHF cells form an epithelial layer in splanchnic mesoderm in the dorsal wall of the pericardial cavity. Here we report oriented cell elongation, polarized actomyosin distribution and nuclear YAP/TAZ in a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actomyosin
Share to Embryo, Mammalian
Share to Epithelium

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Organogenesis

Share to Pericardium

Share to Stress, Mechanical

Share to T-Box Domain Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 28357999
DOI: 10.1038/ncomms14770
PMCID: PMC5379109

Genes

SHF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epithelial tension in the second heart field promotes mouse heart tube elongation.PMID 28357999Read ↗

Epithelial Properties of the Second Heart FieldSemantic proximity Read ↗

TBX1 regulates epithelial polarity and dynamic basal filopodia in the second heart fieldSemantic proximity Read ↗

The mesodermal source of fibronectin is required for heart morphogenesis and cardiac outflow tract elongation by regulating cell shape, polarity, and mechanotransduction in the second heart fieldSemantic proximity Read ↗

Anisotropic stress orients remodelling of mammalian limb bud ectoderm.Semantic proximity Read ↗

Loss of Wnt5a disrupts second heart field cell deployment and may contribute to OFT malformations in DiGeorge syndromeSemantic proximity Read ↗

Anisotropic organization of circumferential actomyosin characterizes hematopoietic stem cells emergence in the zebrafish.Semantic proximity Read ↗

Tissue surface mechanics constrains proliferation-driven forces to guide mammalian body axis elongationSemantic proximity Read ↗

A new hypothesis for foregut and heart tube formation based on differential growth and actomyosin contractionSemantic proximity Read ↗

Cardiac progenitors auto-regulate second heart field cell fate via Wnt secretionSemantic proximity Read ↗

Live imaging of heart tube development in mouse reveals alternating phases of cardiac differentiation and morphogenesisSemantic proximity Read ↗

Mechanical Coupling between Endoderm Invagination and Axis Extension in Drosophila.Semantic proximity Read ↗

PTK7 is essential for polarized cell motility and convergent extension during mouse gastrulation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.