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Article

Anisotropic stress orients remodelling of mammalian limb bud ectoderm.

Nature cell biology - 1 May 2015

Lau Kimberly, Tao Hirotaka, Liu Haijiao, Wen Jun, Sturgeon Kendra, Sorfazlian Natalie, Lazic Savo, Burrows Jeffrey T A, Wong Michael D, Li Danyi, Deimling Steven, Ciruna Brian, Scott Ian, Simmons Craig, Henkelman R Mark, Williams Trevor, Hadjantonakis Anna-Katerina, Fernandez-Gonzalez Rodrigo, Sun Yu, Hopyan Sevan

Abstract excerpt

The physical forces that drive morphogenesis are not well characterized in vivo, especially among vertebrates. In the early limb bud, dorsal and ventral ectoderm converge to form the apical ectodermal ridge (AER), although the underlying mechanisms are unclear. By live imaging mouse embryos, we show that prospective AER progenitors intercalate at the dorsoventral boundary and that ectoderm remodels by concomitant...

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Identifiers

PMID: 25893915
DOI: 10.1038/ncb3156
PMCID: PMC4955842

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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