Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TBX1 regulates epithelial polarity and dynamic basal filopodia in the second heart field

4 Nov 2014

Abstract excerpt

Elongation of the vertebrate heart occurs by progressive addition of second heart field (SHF) cardiac progenitor cells from pharyngeal mesoderm to the poles of the heart tube. The importance of these cells in the etiology of congenital heart defects has led to extensive research into the regulation of SHF deployment by signaling pathways and transcription factors. However, the basic cellular features of these...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Congenital heart defects research
Share to Congenital Heart Disease Studies
Share to Developmental Biology and Gene Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25371366
DOI: 10.1242/dev.115022

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TBX1 regulates epithelial polarity and dynamic basal filopodia in the second heart fieldPMID 25371366Read ↗

Epithelial Properties of the Second Heart FieldSemantic proximity Read ↗

Tbx1 coordinates addition of posterior second heart field progenitor cells to the arterial and venous poles of the heart.Semantic proximity Read ↗

Epithelial tension in the second heart field promotes mouse heart tube elongation.Semantic proximity Read ↗

A fate map of Tbx1 expressing cells reveals heterogeneity in the second cardiac fieldSemantic proximity Read ↗

<i>Tbx1</i> regulates extracellular matrix-cell interactions in the second heart fieldSemantic proximity Read ↗

The mesodermal source of fibronectin is required for heart morphogenesis and cardiac outflow tract elongation by regulating cell shape, polarity, and mechanotransduction in the second heart fieldSemantic proximity Read ↗

Rac1 Signaling Is Critical to Cardiomyocyte Polarity and Embryonic Heart DevelopmentSemantic proximity Read ↗

Tbx1 regulates extracellular matrix-cell interactions in the second heart fieldSemantic proximity Read ↗

T-box genes and retinoic acid signaling regulate the segregation of arterial and venous pole progenitor cells in the murine second heart fieldSemantic proximity Read ↗

Vangl2-regulated polarisation of second heart field-derived cells is required for outflow tract lengthening during cardiac development.Semantic proximity Read ↗

Hoxb1 regulates proliferation and differentiation of second heart field progenitors in pharyngeal mesoderm and genetically interacts with Hoxa1 during cardiac outflow tract development.Semantic proximity Read ↗

Hox-dependent coordination of mouse cardiac progenitor cell patterning and differentiationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.