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Article

Mechanical Coupling between Endoderm Invagination and Axis Extension in Drosophila.

PLoS biology - 1 Jan 2015

Lye Claire M, Blanchard Guy B, Naylor Huw W, Muresan Leila, Huisken Jan, Adams Richard J, Sanson Bénédicte

Abstract excerpt

How genetic programs generate cell-intrinsic forces to shape embryos is actively studied, but less so how tissue-scale physical forces impact morphogenesis. Here we address the role of the latter during axis extension, using Drosophila germband extension (GBE) as a model. We found previously that cells elongate in the anteroposterior (AP) axis in the extending germband, suggesting that an extrinsic tensile force...

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Identifiers

PMID: 26544693
DOI: 10.1371/journal.pbio.1002292
PMCID: PMC4636290

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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