Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Myocardin-related transcription factor-a controls myofibroblast activation and fibrosis in response to myocardial infarction.

Circulation research - 23 Jul 2010

Small Eric M, Thatcher Jeffrey E, Sutherland Lillian B, Kinoshita Hideyuki, Gerard Robert D, Richardson James A, Dimaio J Michael, Sadek Hesham, Kuwahara Koichiro, Olson Eric N

Abstract excerpt

RATIONALE: Myocardial infarction (MI) results in loss of cardiac myocytes in the ischemic zone of the heart, followed by fibrosis and scar formation, which diminish cardiac contractility and impede angiogenesis and repair. Myofibroblasts, a specialized cell type that switches from a fibroblast-like state to a contractile, smooth muscle-like state, are believed to be primarily responsible for fibrosis of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amides
Share to Angiotensin II

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Transdifferentiation

Share to Collagen Type I

Share to Fibrosis

Share to Myocytes, Smooth Muscle

Share to rho-Associated Kinases

Share to Ventricular Remodeling

Source

Open in PubMed Open full text

Identifiers

PMID: 20558820
DOI: 10.1161/CIRCRESAHA.110.223172
PMCID: PMC2921870

Genes

SRF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Myocardin-related transcription factor-a controls myofibroblast activation and fibrosis in response to myocardial infarction.PMID 20558820Read ↗

The actin-MRTF-SRF gene regulatory axis and myofibroblast differentiation.Semantic proximity Read ↗

Myocardin-related Transcription Factor-A Complexes Activate Type I Collagen Expression in Lung FibroblastsSemantic proximity Read ↗

Myocardin-Related Transcription Factor A Is a Common Mediator of Mechanical Stress- and Neurohumoral Stimulation-Induced Cardiac Hypertrophic Signaling Leading to Activation of Brain Natriuretic Peptide Gene ExpressionSemantic proximity Read ↗

Activation of MRTF-A–dependent gene expression with a small molecule promotes myofibroblast differentiation and wound healingSemantic proximity Read ↗

The Role of the TGF-β Superfamily in Myocardial InfarctionSemantic proximity Read ↗

Molecular networks underlying myofibroblast fate and fibrosis.Semantic proximity Read ↗

Cardiac and perivascular myofibroblasts, matrifibrocytes, and immune fibrocytes in hypertension; commonalities and differences with other cardiovascular diseases.Semantic proximity Read ↗

LRRC8A critically regulates myofibroblast phenotypes and fibrotic remodeling following myocardial infarction.Semantic proximity Read ↗

YAP/TAZ deficiency reprograms macrophage phenotype and improves infarct healing and cardiac function after myocardial infarction.Semantic proximity Read ↗

Myocardin-related transcription factor A (MRTF-A) plays an essential role in hepatic stellate cell activation by epigenetically modulating TGF-β signalingSemantic proximity Read ↗

Myocardin-related transcription factor B is required for normal mouse vascular development and smooth muscle gene expression.Semantic proximity Read ↗

Multiomics reveals epigenetic control of fibroblast activity after myocardial infarction and a key role for RUNX transcription factorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.