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Article

Left Ventricular Dysfunction Switches Mesenchymal Stromal Cells Toward an Inflammatory Phenotype and Impairs Their Reparative Properties Via Toll-Like Receptor-4.

Circulation - 6 Jun 2017

Naftali-Shani Nili, Levin-Kotler La-Paz, Palevski Dahlia, Amit Uri, Kain David, Landa Natalie, Hochhauser Edith, Leor Jonathan

Abstract excerpt

BACKGROUND: Little is known about the potentially unfavorable effects of mesenchymal stromal cell (MSC) activation on the heart. MSCs can respond to tissue injury by anti- or proinflammatory activation. We aimed to study the potential negative interaction between left ventricular dysfunction (LVD) and MSC activation. METHODS: We isolated MSCs from cardiac and subcutaneous fat tissues of mice with LVD 28 days...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28356441
DOI: 10.1161/CIRCULATIONAHA.116.023527

Genes

TLR4
MSC

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