Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Toll-like receptor 5 deficiency exacerbates cardiac injury and inflammation induced by myocardial ischaemia-reperfusion in the mouse.

Clinical science (London, England : 1979) - 1 Jul 2015

Parapanov Roumen, Lugrin Jérôme, Rosenblatt-Velin Nathalie, Feihl François, Waeber Bernard, Milano Giuseppina, Vergely Catherine, Li Na, Pacher Pal, Liaudet Lucas

Abstract excerpt

Myocardial ischaemia-reperfusion (MIR) triggers a sterile inflammatory response important for myocardial healing, but which may also contribute to adverse ventricular remodelling. Such inflammation is initiated by molecular danger signals released by damaged myocardium, which induce innate immune responses by activating toll-like receptors (TLRs). Detrimental roles have been recently reported for TLR2, TLR3 and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Inflammation Mediators
Share to Myocardial Infarction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Myocardial Reperfusion Injury

Share to p38 Mitogen-Activated Protein Kinases

Share to Proto-Oncogene Proteins c-akt

Share to Toll-Like Receptor 5

Share to Ventricular Dysfunction, Left

Share to Ventricular Function, Left

Source

Identifiers

PMID: 25757463
DOI: 10.1042/CS20140444

Genes

TLR5
TLR2
TLR3
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Toll-like receptor 5 deficiency exacerbates cardiac injury and inflammation induced by myocardial ischaemia-reperfusion in the mouse.PMID 25757463Read ↗

Toll-like receptor 2 dominance over Toll-like receptor 4 in stressful conditions for its detrimental role in the heart.Semantic proximity Read ↗

Toll-like receptor 4 contributes to a myofibroblast phenotype in cardiac fibroblasts and is associated with autophagy after myocardial infarction in a mouse modelSemantic proximity Read ↗

Deficiency in TLR4 signal transduction ameliorates cardiac injury and cardiomyocyte contractile dysfunction during ischemia.Semantic proximity Read ↗

Toll-like receptor modulation in cardiovascular disease: a target for intervention?Semantic proximity Read ↗

Toll-like receptors in cardiac hypertrophySemantic proximity Read ↗

Toll-Like Receptors: Are They Taking a Toll on the Heart in Viral Myocarditis?Semantic proximity Read ↗

CXADR-like membrane protein protects against heart injury by preventing excessive pyroptosis after myocardial infarction.Semantic proximity Read ↗

Deletion of the ion channel <i>Trpm4</i> increases cardiac inflammatory markers and fibrosis after myocardial infarction in miceSemantic proximity Read ↗

The Role of Toll-Like Receptor Signaling in the Progression of Heart FailureSemantic proximity Read ↗

The Study on the Role and Mechanism of HMGB1-Mediated TLR4/NLRP3/Caspase-1 Signaling Pathway in Regulating Cardiomyocyte Pyroptosis and Myocardial Injury Induced by Myocardial InfarctionSemantic proximity Read ↗

Haematopoietic and cardiac GPR55 synchronize post-myocardial infarction remodellingSemantic proximity Read ↗

Left Ventricular Dysfunction Switches Mesenchymal Stromal Cells Toward an Inflammatory Phenotype and Impairs Their Reparative Properties Via Toll-Like Receptor-4.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.