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p53-dependent SIRT6 expression protects Aβ42-induced DNA damage

9 May 2016

Abstract excerpt

Alzheimer's disease (AD) is the most common type of dementia and age-related neurodegenerative disease. Elucidating the cellular changes that occur during ageing is an important step towards understanding the pathogenesis and progression of neurodegenerative disorders. SIRT6 is a member of the mammalian sirtuin family of anti-aging genes. However, the relationship between SIRT6 and AD has not yet been elucidated....

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PMID: 27156849
DOI: 10.1038/srep25628

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