Article
Interaction between smoking and ATG16L1T300A triggers Paneth cell defects in Crohn's disease.
The Journal of clinical investigation - 1 Nov 2018
Liu Ta-Chiang, Kern Justin T, VanDussen Kelli L, Xiong Shanshan, Kaiko Gerard E, Wilen Craig B, Rajala Michael W, Caruso Roberta, Holtzman Michael J, Gao Feng, McGovern Dermot Pb, Nunez Gabriel, Head Richard D, Stappenbeck Thaddeus S
Abstract excerpt
It is suggested that subtyping of complex inflammatory diseases can be based on genetic susceptibility and relevant environmental exposure (G+E). We propose that using matched cellular phenotypes in human subjects and corresponding preclinical models with the same G+E combinations is useful to this end. As an example, defective Paneth cells can subtype Crohn's disease (CD) subjects; Paneth cell defects have been...
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