New var reconstruction algorithm exposes high var sequence diversity in a single geographic location in Mali.

doi:10.1186/s13073-017-0422-4

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Article

New var reconstruction algorithm exposes high var sequence diversity in a single geographic location in Mali.

Genome medicine - 28 Mar 2017

Dara Antoine, Drábek Elliott F, Travassos Mark A, Moser Kara A, Delcher Arthur L, Su Qi, Hostelley Timothy, Coulibaly Drissa, Daou Modibo, Dembele Ahmadou, Diarra Issa, Kone Abdoulaye K, Kouriba Bourema, Laurens Matthew B, Niangaly Amadou, Traore Karim, Tolo Youssouf, Fraser Claire M, Thera Mahamadou A, Djimde Abdoulaye A, Doumbo Ogobara K, Plowe Christopher V, Silva Joana C

Abstract excerpt

BACKGROUND: Encoded by the var gene family, highly variable Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP1) proteins mediate tissue-specific cytoadherence of infected erythrocytes, resulting in immune evasion and severe malaria disease. Sequencing and assembling the 40-60 var gene complement for individual infections has been notoriously difficult, impeding molecular epidemiological studies and the...

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PMID: 28351419
DOI: 10.1186/s13073-017-0422-4
PMCID: PMC5368897

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