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Global genetic diversity of var2csa in Plasmodium falciparum with implications for malaria in pregnancy and vaccine development

12 Oct 2018

Abstract excerpt

Malaria infection during pregnancy, caused by the sequestering of Plasmodium falciparum parasites in the placenta, leads to high infant mortality and maternal morbidity. The parasite-placenta adherence mechanism is mediated by the VAR2CSA protein, a target for natural occurring immunity. Currently, vaccine development is based on its ID1-DBL2Xb domain however little is known about the global genetic diversity of...

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PMID: 30337594
DOI: 10.1038/s41598-018-33767-3

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Research trail→

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Global genetic diversity of var2csa in Plasmodium falciparum with implications for malaria in pregnancy and vaccine developmentPMID 30337594Read ↗

Genetic diversity of VAR2CSA ID1-DBL2Xb in worldwide Plasmodium falciparum populations: impact on vaccine design for placental malaria.Semantic proximity Read ↗

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Structural insights into global mutations in the ligand-binding domain of VAR2CSA and its implications on placental malaria vaccine.Semantic proximity Read ↗

Global genetic diversity and evolution of var genes associated with placental and severe childhood malaria.Semantic proximity Read ↗

Identification of a Major Dimorphic Region in the Functionally Critical N-Terminal ID1 Domain of VAR2CSA.Semantic proximity Read ↗

Two divergent VAR2CSA lineages with distinct evolutionary signatures circulate in Plasmodium falciparum from Thailand.Semantic proximity Read ↗

Evaluation of the Antigenic Diversity of Placenta-Binding Plasmodium falciparum Variants and the Antibody Repertoire among Pregnant WomenSemantic proximity Read ↗

A systematic review on genetic diversity of var gene DBL1α domain from different geographical regions in Plasmodium falciparum isolates.Semantic proximity Read ↗

Allelic variants of full-length VAR2CSA, the placental malaria vaccine candidate, differ in antigenicity and receptor binding affinitySemantic proximity Read ↗

Plasmodium falciparum genetic variation of var2csa in the Democratic Republic of the Congo.Semantic proximity Read ↗

Structural insight into epitopes in the pregnancy-associated malaria protein VAR2CSA.Semantic proximity Read ↗

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