Article
A molecular epidemiological study of var gene diversity to characterize the reservoir of Plasmodium falciparum in humans in Africa.
PloS one - 9 Feb 2011
Chen Donald S, Barry Alyssa E, Leliwa-Sytek Aleksandra, Smith Terry-Ann, Peterson Ingrid, Brown Stuart M, Migot-Nabias Florence, Deloron Philippe, Kortok Moses M, Marsh Kevin, Daily Johanna P, Ndiaye Daouda, Sarr Ousmane, Mboup Souleymane, Day Karen P
Abstract excerpt
BACKGROUND: The reservoir of Plasmodium infection in humans has traditionally been defined by blood slide positivity. This study was designed to characterize the local reservoir of infection in relation to the diverse var genes that encode the major surface antigen of Plasmodium falciparum blood stages and underlie the parasite's ability to establish chronic infection and transmit from human to mosquito....
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