Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Placental malaria vaccine candidate antigen VAR2CSA displays atypical domain architecture in some Plasmodium falciparum strains

6 Dec 2019

Abstract excerpt

Abstract Two vaccines based on Plasmodium falciparum protein VAR2CSA are currently in clinical evaluation to prevent placental malaria (PM), but a deeper understanding of var2csa variability could impact vaccine design. Here we identified atypical extended or truncated VAR2CSA extracellular structures and confirmed one extended structure in a Malian maternal isolate, using a novel protein fragment assembly method...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Complement system in diseases
Share to HIV Research and Treatment
Share to Malaria Research and Control

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31840102
DOI: 10.1038/s42003-019-0704-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Placental malaria vaccine candidate antigen VAR2CSA displays atypical domain architecture in some Plasmodium falciparum strainsPMID 31840102Read ↗

Global genetic diversity of var2csa in Plasmodium falciparum with implications for malaria in pregnancy and vaccine developmentSemantic proximity Read ↗

Structural insights into global mutations in the ligand-binding domain of VAR2CSA and its implications on placental malaria vaccine.Semantic proximity Read ↗

Structural basis for placental malaria mediated by Plasmodium falciparum VAR2CSA.Semantic proximity Read ↗

Allelic variants of full-length VAR2CSA, the placental malaria vaccine candidate, differ in antigenicity and receptor binding affinitySemantic proximity Read ↗

Genetic diversity of VAR2CSA ID1-DBL2Xb in worldwide Plasmodium falciparum populations: impact on vaccine design for placental malaria.Semantic proximity Read ↗

Increased risk of low birth weight in women with placental malaria associated with P. falciparum VAR2CSA clade.Semantic proximity Read ↗

Global genetic diversity and evolution of var genes associated with placental and severe childhood malaria.Semantic proximity Read ↗

A single full-length VAR2CSA ectodomain variant purifies broadly neutralizing antibodies against placental malaria isolatesSemantic proximity Read ↗

Structural insight into epitopes in the pregnancy-associated malaria protein VAR2CSA.Semantic proximity Read ↗

New var reconstruction algorithm exposes high var sequence diversity in a single geographic location in Mali.Semantic proximity Read ↗

Cryo-EM reveals the architecture of placental malaria VAR2CSA and provides molecular insight into chondroitin sulfate bindingSemantic proximity Read ↗

Epitope mapping and topographic analysis of VAR2CSA DBL3X involved in P. falciparum placental sequestration.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.