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Article

Oncogenic BRAF disrupts thyroid morphogenesis and function via twist expression

28 Mar 2017

Abstract excerpt

Thyroid cancer is common, yet the sequence of alterations that promote tumor formation are incompletely understood. Here, we describe a novel model of thyroid carcinoma in zebrafish that reveals temporal changes due to BRAF V600E . Through the use of real-time in vivo imaging, we observe disruption in thyroid follicle structure that occurs early in thyroid development. Combinatorial treatment using BRAF and MEK...

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PMID: 28350298
DOI: 10.7554/elife.20728

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