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Article

Dual targeting of MAPK and PI3K pathways unlocks redifferentiation of Braf-mutated thyroid cancer organoids.

Oncogene - 1 Jan 2024

Lasolle Hélène, Schiavo Andrea, Tourneur Adrien, Gillotay Pierre, de Faria da Fonseca Bárbara, Ceolin Lucieli, Monestier Olivier, Aganahi Benilda, Chomette Laura, Kizys Marina Malta Letro, Haenebalcke Lieven, Pieters Tim, Goossens Steven, Haigh Jody, Detours Vincent, Maia Ana Luiza Silva, Costagliola Sabine, Romitti Mírian

Abstract excerpt

Thyroid cancer is the most common endocrine malignancy and several genetic events have been described to promote the development of thyroid carcinogenesis. Besides the effects of specific mutations on thyroid cancer development, the molecular mechanisms controlling tumorigenesis, tumor behavior, and drug resistance are still largely unknown. Cancer organoids have been proposed as a powerful tool to study aspects...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37985676
DOI: 10.1038/s41388-023-02889-y
PMCID: PMC10786723

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