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Article

Tissue architecture delineates field cancerization in BRAFV600E-induced tumor development.

Disease models & mechanisms - 1 Feb 2022

Schoultz Elin, Johansson Ellen, Moccia Carmen, Jakubikova Iva, Ravi Naveen, Liang Shawn, Carlsson Therese, Montelius Mikael, Patyra Konrad, Kero Jukka, Paulsson Kajsa, Fagman Henrik, Bergo Martin O, Nilsson Mikael

Abstract excerpt

Cancer cells hijack developmental growth mechanisms but whether tissue morphogenesis and architecture modify tumorigenesis is unknown. Here, we characterized a new mouse model of sporadic thyroid carcinogenesis based on inducible expression of BRAF carrying a Val600 Glu (V600E) point mutation (BRAFV600E) from the thyroglobulin promoter (TgCreERT2). Spontaneous activation of this Braf-mutant allele due to leaky...

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Identifiers

PMID: 34379110
DOI: 10.1242/dmm.048887
PMCID: PMC8380047

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