Article
Alterations in genomic profiles during tumor progression in a mouse model of follicular thyroid carcinoma.
Carcinogenesis - 1 Sept 2003
Ying Hao, Suzuki Hideyo, Furumoto Hiroko, Walker Robert, Meltzer Paul, Willingham Mark C, Cheng Sheue-Yann
Abstract excerpt
The molecular genetics underlying thyroid carcinogenesis is not well understood. We have recently created a mutant mouse by targeting a mutation (PV) into the thyroid hormone receptor beta gene (TRbetaPV mouse). TRbetaPV/PV mice spontaneously develop follicular thyroid carcinoma through pathologi...
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