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Article

TWIST1 plays a pleiotropic role in determining the anaplastic thyroid cancer phenotype.

The Journal of clinical endocrinology and metabolism - 1 May 2011

Salerno Paolo, Garcia-Rostan Ginesa, Piccinin Sara, Bencivenga Tammaro Claudio, Di Maro Gennaro, Doglioni Claudio, Basolo Fulvio, Maestro Roberta, Fusco Alfredo, Santoro Massimo, Salvatore Giuliana

Abstract excerpt

CONTEXT: Anaplastic thyroid carcinoma (ATC) is one of the most aggressive human tumors; it is characterized by chemoresistance, local invasion, and distant metastases. ATC is invariably fatal. OBJECTIVE: The aim was to study the role of TWIST1, a basic helix-loop-helix transcription factor, in ATC. DESIGN: Expression of TWIST1 was studied by immunohistochemistry and real-time PCR in normal thyroids and...

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Source

Identifiers

PMID: 21389145
DOI: 10.1210/jc.2010-1182

Genes

TWIST1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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