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Article

State-dependent inter-repeat contacts of exceptionally conserved asparagines in the inner helices of sodium and calcium channels.

Pflugers Archiv : European journal of physiology - 1 Feb 2015

Tikhonov Denis B, Bruhova Iva, Garden Daniel P, Zhorov Boris S

Abstract excerpt

Voltage-gated sodium and calcium channels play key roles in the physiology of excitable cells. The alpha-1 subunit of these channels folds from a polypeptide chain of four homologous repeats. In each repeat, the cytoplasmic halves of the pore-lining helices contain exceptionally conserved asparagines. Such conservation implies important roles, which are unknown. Mutations of the asparagines affect activation and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24728659
DOI: 10.1007/s00424-014-1508-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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