Article

Longitudinal functional network connectivity changes across the clinical stages of <i>C9orf72</i> hexanucleotide repeat expansion carriers

2025-11-27

Abstract excerpt

<h4>ABSTRACT</h4> <h4>INTRODUCTION</h4> Intrinsic functional connectivity network abnormalities in C9orf72 hexanucleotide repeat expansion carriers emerge during the asymptomatic phase, yet longitudinal studies remain limited. We examined cross-sectional abnormalities and longitudinal connectivity changes across clinical stages. <h4>METHODS</h4> We analyzed task-free fMRI and structural MRI data in 36 asympto...

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Literature Corpus work: 66452fc4-46ec-53ca-bdc1-19ec4ed261a8
DOI: 10.1101/2025.11.23.25340528

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