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Article

Longitudinal changes in network homogeneity in presymptomatic C9orf72 mutation carriers.

Neurobiology of aging - 1 Mar 2021

Waugh Rebecca E, Danielian Laura E, Shoukry Rachel F Smallwood, Floeter Mary Kay

Abstract excerpt

The risk for carriers of repeat expansion mutations in C9orf72 to develop amyotrophic lateral sclerosis and frontotemporal dementia increases with age. Functional magnetic resonance imaging studies have shown reduced connectivity in symptomatic carriers, but it is not known whether connectivity declines throughout life as an acceleration of the normal aging pattern. In this study, we examined intra-network...

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Identifiers

PMID: 33421737
DOI: 10.1016/j.neurobiolaging.2020.11.014
PMCID: PMC11428095

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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