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Article

Membrane Topology of the Human Dipeptide Transporter, hPEPT1, Determined by Epitope Insertions

1 Oct 1998

Abstract excerpt

We have used epitope insertion to analyze the transmembrane topology of the human H+-dipeptide symporter hPEPT1. An epitope tag, EYMPME (EE), was inserted into different locations at amino acids 39, 78, 106, 412, and 708 of hPEPT1 by site-directed mutagenesis. The functional integrity of the tagged protein was tested by measuring its dipeptide transport activity in transfected Cos7 cells. Further, cells...

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PMID: 9790685
DOI: 10.1021/bi981128k

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